6533b838fe1ef96bd12a463a
RESEARCH PRODUCT
Characterization of PLLA scaffolds for biomedical applications
Francesco Carfì PaviaValerio BrucatoVincenzo La CarrubbaGianluca TurcoGabriele GrassiSimona Maria FiorentinoRossella FarraMichela AbramiMario Grassisubject
Pore sizeScaffoldMaterials sciencePolymers and PlasticsGeneral Chemical EngineeringNanotechnology02 engineering and technologyscaffold010402 general chemistry01 natural sciencesPLLAAnalytical ChemistryTissue engineeringpore size distributionChemical Engineering (all)PorositySettore ING-IND/24 - Principi Di Ingegneria Chimicaintegumentary systemLow-field NMR; phase separation; PLLA; pore size distribution; scaffold; Analytical Chemistry; Chemical Engineering (all); Polymers and Plastics021001 nanoscience & nanotechnology0104 chemical sciencesCharacterization (materials science)Settore ING-IND/22 - Scienza E Tecnologia Dei MaterialiWound dressingDrug deliveryphase separation0210 nano-technologyLow-field NMRdescription
The porosity and pore size distribution of three-dimensional scaffolds have direct implications on their biomedical applications (tissue engineering, drug delivery, and wound dressing). Accordingly, in this paper, a fast, facile, and conservative method relying on low-field nuclear magnetic resonance (LF-NMR) for the evaluation of mean pore size and pore size distribution of polymeric scaffolds is reported. The applicability of the technique is demonstrated on poly-L-lactic acid scaffolds fabricated using the thermal induced phase separation. Results obtained through LF-NMR are successfully compared to scanning electron microscope and X-ray microcomputed tomography micrographs.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-04-12 |