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RESEARCH PRODUCT
ChemInform Abstract: Enantioselective Addition of Nitromethane to α-Keto Esters Catalyzed by Copper(II)-Iminopyridine Complexes.
Gonzalo BlayJosé R. PedroVictor Hernandez‐olmossubject
chemistry.chemical_classificationCopper complexKetoneNitromethaneEnantioselective synthesischemistry.chemical_elementGeneral MedicineCarbonyl groupCopperMedicinal chemistryCatalysischemistry.chemical_compoundchemistrylipids (amino acids peptides and proteins)Alkyldescription
The copper complex of a chiral iminopyridine easily prepared from (R)-(−)-fenchone and picolylamine catalyzes the enantioselective Henry (nitroaldol) reaction between nitromethane and α-keto esters. Good yields and modest to good enantioselectivities are obtained for a wide range of α-keto esters, bearing aromatic, alkyl or alkenyl groups attached to the ketone carbonyl group.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2008-06-24 | ChemInform |