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RESEARCH PRODUCT

Biophysical Characterization of TRPV2 Ion Channel

Hitoshi InadaAlex Perálvarez-marínRachelle GaudetIsmael MingarroPablo Doñate-macián

subject

Orphan receptorTransient receptor potential channelOrder (biology)BiochemistrySequence analysisBiophysicsBiophysicsBiologyProtein secondary structureTopology (chemistry)Function (biology)Ion channel

description

TRPV2 is a member of the superfamily of the Transient Receptor Potential (TRP) ion channels. These channels are assembled into homotetramers and allow cations across the membrane in response to physico-chemical stimuli such as heat, pressure, osmotic changes, etc. TRPV2 is an orphan receptor, since no specific endogenous ligand has been identified yet. To better understand the role of TRPV2 and to go further into its function, sequence analysis of orthologs for TRPV2 has been performed in order to define common and differential architectural regions. Preliminary biophysical characterization such as thermal stability, and secondary structure composition analysis has been carried out on the different TRPV2 orthologs to identify key structural points in the TRPV2 topology.

yearjournalcountryeditionlanguage
2012-01-01Biophysical Journal
10.1016/j.bpj.2011.11.1876http://dx.doi.org/10.1016/j.bpj.2011.11.1876