6533b838fe1ef96bd12a509d
RESEARCH PRODUCT
Communication: Protein dynamical transition vs. liquid-liquid phase transition in protein hydration water
Giorgio SchiròMargarita FominaAntonio Cupanesubject
Quantitative Biology::BiomoleculesPhase transitionProperties of waterMyoglobinSolvationWaterGeneral Physics and AstronomyNeutron scatteringPhase TransitionCritical point (mathematics)chemistry.chemical_compoundDifferential scanning calorimetryMyoglobinchemistryChemical physicsThermodynamicsPhysical chemistryPhysical and Theoretical ChemistrySupercoolingdescription
In this work, we compare experimental data on myoglobin hydrated powders from elastic neutron scattering, broadband dielectric spectroscopy, and differential scanning calorimetry. Our aim is to obtain new insights on the connection between the protein dynamical transition, a fundamental phenomenon observed in proteins whose physical origin is highly debated, and the liquid-liquid phase transition (LLPT) possibly occurring in protein hydration water and related to the existence of a low temperature critical point in supercooled water. Our results provide a consistent thermodynamic/dynamic description which gives experimental support to the LLPT hypothesis and further reveals how fundamental properties of water and proteins are tightly related.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-09-28 | The Journal of Chemical Physics |