6533b838fe1ef96bd12a5328
RESEARCH PRODUCT
Design of a multifunctionalizable BODIPY platform for the facile elaboration of a large series of gold(i)-based optical theranostics.
Jacques PliquettJacques PliquettJacques PliquettCatherine PaulCatherine PaulPaul Fleurat-lessardEwen BodioAli BettaiebAli BettaiebYoann RousselinSouheila AmorChristine GozeFranck DenatMyriam LalyCindy RacoeurCindy RacoeurMiguel Ponce-vargassubject
Materials science010405 organic chemistryLarge seriesNanotechnology010402 general chemistry01 natural sciences0104 chemical sciencesInorganic Chemistrychemistry.chemical_compoundchemistryConfocal imagingBODIPYCancer cell linesHigh potentialElaborationdescription
A simple trifunctional BODIPY platform was designed. The high potential of this platform was validated via the elaboration of twelve optical theranostics. More specifically, we reported on the synthesis, the characterization, the photophysical properties, and the evaluation of the hydrophilicity properties of the different BODIPY derivatives, as well as a theoretical rationalization of the intriguing chemical behavior of some of them. The antiproliferative evaluation and confocal imaging of the different compounds in three human and murine cancer cell lines were performed and analysed, along with the measurement of gold(I) uptake in one cancer cell line via ICP-MS.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-07-28 | Dalton transactions (Cambridge, England : 2003) |