Modificētās L-ornitīna δ-aminotransferāzes strukturālie pētījumi jaunu diazonamīda A struktūranalogu dizainam

6533b839fe1ef96bd12a553e

RESEARCH PRODUCT

Modificētās L-ornitīna δ-aminotransferāzes strukturālie pētījumi jaunu diazonamīda A struktūranalogu dizainam

Andris Baltvilks

subject

racionālais zāļu dizains proteīnu rentgenstruktūranalīze modificētā ornitīna δ-aminotransferāze Bioloģija proteīnu kristalizācija proteīnu attīrīšana

description

Darba mērķi ir izstrādāt metodi rekombinantas modificētās ornitīna δ-aminotransferāzes (MOAT) produkcijai un kristalizēšanai, analizēt MOAT strukturālās atšķirības no ornitīna δ-aminotransferāzes (OAT), kā arī noteikt MOAT kristālu struktūru kompleksā ar Latvijas Organiskās sintēzes institūta pētnieku sintezētajiem diazonamīda A struktūranalogiem. Tādejādi, varētu noteikt MOAT un diazonamīda A struktūranalogu ķīmisko mijiedarbību veidu, iegūstot zināšanas jaunu MOAT inhibitoru dizainam. Bakalaura darba laikā tika iegūts rekombinants, E.coli producēts, MOAT, kā arī MOAT kristālstruktūra kompleksā ar piridoksāla 5´ fosfātu. Bakalaura darbs tika izstrādāts Latvijas Biomedicīnas pētījumu un studiju centrā, proteīnu kristalogrāfijas laboratorijā, Dr. biol. Kaspara Tāra vadībā.

year	journal	country	edition	language
2015-01-01

https://dspace.lu.lv/dspace/handle/7/29447

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