6533b839fe1ef96bd12a5790

RESEARCH PRODUCT

Synthesis and antirpoliferative activity of isoxazolo[3,4-d]pyridazin-7(6H)-one derivatives

B. MaggioG. CancemiM. RaimondiF. PlesciaS. CascioferroM. CusimanoM. LauricellaD. CarlisiG. DaidoneD. Raffa

subject

Settore BIO/10 - Biochimicaisoxazolo[34-d]pyridazin-7(6H)-ones antiproliferative activity DNA interactionSettore CHIM/08 - Chimica Farmaceutica

description

3,4-diphenylisoxazolo[3,4-d]pyridazin-7(6H)-one analogs were synthesized and tested for the antiproliferative activity. Study on the cell cycle alteration and on some cellular target (ATM, procaspase-2 proteins and H2AX histone) demonstrate the increase of the cell population in S phase and to induce cellular death by apoptosis by DNA damage with double strand breaks.

yearjournalcountryeditionlanguage
2014-09-01
http://hdl.handle.net/10447/98586