6533b839fe1ef96bd12a5a64

RESEARCH PRODUCT

Electrospinning of α,β-poly(N-2-hydroxyethyl)-dl-aspartamide-graft-polylactic acid to produce a fibrillar scaffold

Filippo CalascibettaGiovanna PitarresiGaetano GiammonaCalogero FioricaFabio Salvatore Palumbo

subject

ELECTROSPINNING PHEA PLA FIBRILLAR SCAFFOLD SCAFFOLD.Materials sciencePolymers and PlasticsOrganic ChemistryGeneral Physics and AstronomyBiomaterialElectrospinningHydrolysischemistry.chemical_compoundPolylactic acidchemistrySettore CHIM/09 - Farmaceutico Tecnologico ApplicativoNanofiberPolymer chemistryDrug deliveryMaterials ChemistryAcetoneCopolymer

description

Abstract α,β-Poly( N -2-hydroxyethyl)- dl -aspartamide grafted with polylactic acid (PHEA- g -PLA) is a biocompatible and biodegradable amphiphilic copolymer that has been already employed to prepare a drug delivery system. In this study we have prepared for the first time a fibrillar scaffold from PHEA- g -PLA by the electrospinning of a solution of this copolymer in a mixture of N , N -dimethyl formamide (DMF) and acetone (80:20 vol/vol). The average diameter and the morphology of electrospun fibers were detected by scanning electron microscopy. Chemical degradation studies in phosphate buffer solution pH 7.4 have been performed until 15 days in order to obtain a preliminary information about the hydrolytic resistance of the prepared scaffold.

yearjournalcountryeditionlanguage
2010-02-01European Polymer Journal
https://doi.org/10.1016/j.eurpolymj.2009.09.001