6533b839fe1ef96bd12a5abc

RESEARCH PRODUCT

Inactivation of electrophilic metabolites by glutathione S-transferases and limitation of the system due to subcellular localization

Franz OeschHansruedi Glatt

subject

MaleSalmonella typhimuriumendocrine systemHealth Toxicology and MutagenesisMutagenToxicologymedicine.disease_causeMicechemistry.chemical_compoundCytosolBiotransformationpolycyclic compoundsmedicineAnimalsBenzopyrenesBiotransformationGlutathione Transferasebiologyfungifood and beveragesGeneral MedicineGlutathioneSubcellular localizationGlutathioneCytosolGlutathione S-transferaseBenzo(a)pyrenechemistryBiochemistryMicrosomes Liverbiology.proteinPyreneMutagens

description

Benzo(a)pyrene was activated to metabolites mutagenic for Salmonella typhimurium TA 98 by liver microsomes from control and phenobarbital treated mice. Under these conditions benzo(a)pyrene 4,5-oxide accounts for most of the mutagenicity. We have therefore investigated (1) the conjugation of benzo(a)pyrene 4,5-oxide with glutathione and (2) the effect of glutathione on the mutagenicity of benzo(a)pyrene.

https://doi.org/10.1007/bf00343278