6533b839fe1ef96bd12a5abc
RESEARCH PRODUCT
Inactivation of electrophilic metabolites by glutathione S-transferases and limitation of the system due to subcellular localization
Franz OeschHansruedi Glattsubject
MaleSalmonella typhimuriumendocrine systemHealth Toxicology and MutagenesisMutagenToxicologymedicine.disease_causeMicechemistry.chemical_compoundCytosolBiotransformationpolycyclic compoundsmedicineAnimalsBenzopyrenesBiotransformationGlutathione Transferasebiologyfungifood and beveragesGeneral MedicineGlutathioneSubcellular localizationGlutathioneCytosolGlutathione S-transferaseBenzo(a)pyrenechemistryBiochemistryMicrosomes Liverbiology.proteinPyreneMutagensdescription
Benzo(a)pyrene was activated to metabolites mutagenic for Salmonella typhimurium TA 98 by liver microsomes from control and phenobarbital treated mice. Under these conditions benzo(a)pyrene 4,5-oxide accounts for most of the mutagenicity. We have therefore investigated (1) the conjugation of benzo(a)pyrene 4,5-oxide with glutathione and (2) the effect of glutathione on the mutagenicity of benzo(a)pyrene.
year | journal | country | edition | language |
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1977-12-30 | Archives of Toxicology |