6533b839fe1ef96bd12a5d11
RESEARCH PRODUCT
Selective expression of galanin in neuronal-like cells of the human carotid body
Camillo Di GiulioGuya Diletta MarconiAndrea Di TanoSusi ZaraCataldi AmeliaAndrea MazzatentaMieczyslaw PokorskiAndrea Porzionatosubject
AdultGenetics and Molecular Biology (all)medicine.medical_specialtyCellGalaninNeuroprotectionBiochemistryCarotid body; Galanin; Hypoxia; Oxygen sensing; Adult; Aged; Carotid Body; Galanin; Humans; Middle Aged; Neurons; Biochemistry Genetics and Molecular Biology (all); Medicine (all)Internal medicinemedicineHumansRespiratory systemGalaninHypoxiaAgedNeuronsCarotid BodybiologyMedicine (all)Hypoxia (medical)Middle AgedOxygen sensingCell biologyEndocrinologymedicine.anatomical_structurenervous systembiology.proteinCarotid bodymedicine.symptomHomeostasisNeurotrophindescription
The carotid body is a neural-crest-derived organ devoted to respiratory homeostasis through sensing changes in blood oxygen levels. The sensory units are the glomeruli composed of clusters of neuronal-like (type I) cells surrounded by glial-like (type II) cells. During chronic hypoxia, the carotid body shows growth, with increasing neuronal-like cell numbers. We are interested in the signals involved in the mechanisms that underlie such response, because they are not well understood and described. Considering that, in literature, galanin is involved in neurotrophic or neuroprotective role in cell proliferation and is expressed in animal carotid body, we investigated its expression in human. Here, we have shown the expression and localisation of galanin in the human carotid body.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-01-01 |