Ilgtermiņa mitohondriju funkcionalitātes traucējumu pētījumi pelēm pēc vidējās cerebrālās artērijas oklūzijas

6533b839fe1ef96bd12a5f66

RESEARCH PRODUCT

Ilgtermiņa mitohondriju funkcionalitātes traucējumu pētījumi pelēm pēc vidējās cerebrālās artērijas oklūzijas

Reinis Maļuhins

subject

oksigrāfs mitohondriji skābekļa patēriņš smadzeņu garoza Farmācija cerebrāls infarkts

description

Mitohondriji ir šūnu enerģijas spēkstacijas, kas oksidatīvās fosforilācijas rezultātā ražo organismam nepieciešamo enerģiju. Išemizēti apstākļi smadzenēs, it īpaši pēc cerebrāla infarkta, var radīt mitohondriju funkcionēšanas traucējumus. Pētījuma mērķis bija izpētīt vidējās cerebrālās artērijas oklūzijas radīto ilgtermiņa ietekmi uz mitohondriālo elpošanu peļu CNS smadzeņu audu struktūrās. Iegūtie maģistra darba rezultāti liecina, ka cerebrāls infarkts pēc diviem, trijiem un četriem mēnešiem būtiski samazina mitohondriju skābekļa patēriņu abās smadzeņu garozas puslodēs un hipokampa struktūrā. Iegūtie rezultāti sniedz jaunas zināšanas un atziņas par ilgtermiņa izmaiņām mitohondriju funkcionēšanā, pirmsklīniski izpētot, to aktivitāti vairākus mēnešus pēc insulta.

year	journal	country	edition	language
2020-01-01

https://dspace.lu.lv/dspace/handle/7/51285

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