Gold-Catalyzed Povarov-Type Reaction of Fluorinated Imino Esters and Furans

6533b839fe1ef96bd12a64d5

RESEARCH PRODUCT

Gold-Catalyzed Povarov-Type Reaction of Fluorinated Imino Esters and Furans

Carlos Del Pozo Santos Fustero Javier Miró María Sánchez-roselló Alvaro Sanz-vidal

subject

010405 organic chemistry Chemistry Organic Chemistry Organic chemistry Povarov reaction 010402 general chemistry 01 natural sciences 0104 chemical sciences Catalysis

description

A gold-catalyzed Povarov-type reaction of fluorinated imino esters and furans is described. The process, which takes place in dichoromethane at room temperature, gives rise to novel fluorinated tetrahydrofuran-fused tetrahydroquinolines in good yields and moderate levels of diastereo-selectivity in a very simple manner. The reported examples expand the versatility of the Povarov reaction to unprecedented fluorinated substrates, generating scaffolds that contain quaternary alpha-amino acid units.

year	journal	country	edition	language
2016-01-01	The Journal of Organic Chemistry

https://doi.org/10.1021/acs.joc.6b01139

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