6533b839fe1ef96bd12a6580
RESEARCH PRODUCT
Highly Enantioselective Friedel−Crafts Alkylations of Indoles with Simple Enones Catalyzed by Zirconium(IV)−BINOL Complexes
Gonzalo BlayIsabel FernándezCarlos VilaJosé R. Pedrosubject
ZirconiumOrganic ChemistryEnantioselective synthesischemistry.chemical_elementGeneral MedicineAlkylationBiochemistryPyrrole derivativesCatalysischemistry.chemical_compoundchemistrySimple (abstract algebra)Organic chemistryPhysical and Theoretical ChemistryFriedel–Crafts reactionPyrroledescription
Complexes of BINOL-based ligands with Zr(OtBu)4 catalyze the Friedel-Crafts alkylation reaction of indoles and pyrrole with nonchelating beta-substituted alpha,beta-enones at room temperature affording the expected products with good yields and ee above 95% in most of the studied examples.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2007-05-25 | Organic Letters |