6533b839fe1ef96bd12a67a3

RESEARCH PRODUCT

Mononuclear Perfluoroalkyl-Heterocyclic Complexes of Pd(II): Synthesis, Structural Characterization and Antimicrobial Activity

Vita Di StefanoPatrizia CancemiRosa AlduinaMaria Assunta GirasoloSilvestre BuscemiIvana PibiriSimona RubinoSantino Orecchio

subject

Denticityperfluoroalkyl heterocyclic ligandsSpectrophotometry InfraredStereochemistryProton Magnetic Resonance SpectroscopyPharmaceutical ScienceMicrobial Sensitivity TestsSettore BIO/19 - Microbiologia GeneraleRing (chemistry)Analytical Chemistrylcsh:QD241-441chemistry.chemical_compoundlcsh:Organic chemistryAnti-Infective AgentsHeterocyclic CompoundsDrug DiscoveryPyridinemononuclear palladium complexesSettore BIO/06 - Anatomia Comparata E CitologiaPhysical and Theoretical ChemistrytriazolesFluorocarbonsantimicrobial activityBacteriaChemistryLigandCommunicationnarcosisOrganic ChemistrySettore CHIM/06 - Chimica OrganicaDNAAntimicrobialSettore CHIM/03 - Chimica Generale E InorganicaChemistry (miscellaneous)Molecular MedicinePalladiumPlasmids

description

Two mononuclear Pd(II) complexes [PdCl2(pfptp)] (1) and [PdCl2(pfhtp)] (2), with ligands 2-(3-perfluoropropyl-1-methyl-1,2,4-triazole-5yl)-pyridine (pfptp) and 2-(3-perfluoroheptyl-1-methyl-1,2,4-triazole-5yl)-pyridine (pfhtp), were synthesized and structurally characterized. The two complexes showed a bidentate coordination of the ligand occurring through N atom of pyridine ring and N4 atom of 1,2,4-triazole. Both complexes showed antimicrobial activity when tested against both Gram-negative and Gram-positive bacterial strains.

yearjournalcountryeditionlanguage
2020-09-01Molecules
https://doi.org/10.3390/molecules25194487