Neirotrofo faktoru ietekme uz neiroektodermas marķieru ekspresiju ādas mezenhimālajās cilmes šūnās

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RESEARCH PRODUCT

Neirotrofo faktoru ietekme uz neiroektodermas marķieru ekspresiju ādas mezenhimālajās cilmes šūnās

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Kultivēšanas barotnes sastāvs ir faktors, kas stimulē cilmes šūnu diferenciāciju in vitro. Neirotrofie faktori virza diferenciāciju neiroektodermas šūnu virzienā. Bakalaura darba mērķis bija analizēt neirotrofo faktoru ietekmi uz neiroektodermas marķieru ekspresiju ādas mezenhimālajās cilmes šūnās (Ā-MCš). Neiroektodermas gēnu ekspresija Ā-MCš tika noteikta ar RT-PCR metodi pēc diferencēšanas trīs barotnēs. Tika izveidots 15 neiroektodermas gēnu praimeru panelis. Sox10, NES un TUBB3 gēni tika analizēti arī ar kvantitatīvo PCR (qPCR) metodi. RT-PCR rezultāti uzrādīja atšķirības Pax6 un S100β gēnu ekspresijā starp barotņu sastāviem. qPCR analīze parādīja, ka Švāna šūnu barotnē pieauga Sox10 ekspresija, neirodiferenciācijas barotnē pieauga TUBB3 ekspresija un NES ekspresija palielinājās gan neirodiferenciācijas, gan Švāna šūnu barotnēs.

year	journal	country	edition	language
2013-01-01

https://dspace.lu.lv/dspace/handle/7/16938

PEPhysical Sciences and Engineering
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