6533b839fe1ef96bd12a6ed3
RESEARCH PRODUCT
T cell factor (interleukin 2) allows in vivo induction of T helper cells against heterologous erythrocytes in athymic (nu/nu) mice.
Hans StötterErwin RüdeHermann Wagnersubject
Interleukin 2ErythrocytesT cellT-LymphocytesImmunologyHeterologousMice NudeBiologymedicine.disease_causeMiceIn vivomedicineImmunology and AllergyAnimalsAntilymphocyte SerumMutationMice Inbred C3HSheepLymphokineT helper cellComplement System ProteinsMolecular biologyMice Inbred C57BLmedicine.anatomical_structureImmunologyImmunocompetencemedicine.drugdescription
Mice carrying the nude mutation (nu/nu) lack a functioning thymus and do not contain detectable levels of immunocompetent T cells. We now report that nu/nu mice do have lymphocytes which can be activated in vivo by heterologous erythrocytes and a Lyt-1 T cell-derived factor (interleukin 2) to generate T helper cells. Thus, a lymphokine is described which is able to restore in vivo T helper cell immunocompetence of nu/nu mice. The data may suggest that nu/nu mice contain a low number of T lymphocytes influenced by the cystic remnant of the nu/nu thymus anlage. Alternatively, the data imply that interleukin 2 circumvents the requirement of a thymus during ontogeny of T lymphocytes.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1980-09-01 | European journal of immunology |