6533b83afe1ef96bd12a705e

RESEARCH PRODUCT

Low Tissue Creatine: A Therapeutic Target in Clinical Nutrition

Sergej M. Ostojic

subject

VDP::Medisinske Fag: 700::Helsefag: 800::Ernæring: 811Nutrition and DieteticsMagnetic Resonance SpectroscopyCreatineMagnetic Resonance ImagingFood Science

description

Low tissue creatine characterizes many conditions, including neurodegenerative, cardiopulmonary, and metabolic diseases, with a magnitude of creatine shortfall often corresponds well to a disorder’s severity. A non-invasive monitoring of tissue metabolism with magnetic resonance spectroscopy (MRS) might be a feasible tool to evaluate suboptimal levels of creatine for both predictive, diagnostic, and therapeutic purposes. This mini review paper summarizes disorders with deficient creatine levels and provides arguments for assessing and employing tissue creatine as a relevant target in clinical nutrition.

10.3390/nu14061230https://hdl.handle.net/11250/3047338