6533b83afe1ef96bd12a7075
RESEARCH PRODUCT
Role of Membrane Lipids for the Activity of Pore Forming Peptides and Proteins
Jesus SalgadoOrlando SánchezSanti Esteban-martínDiana GimenezAna J. García-sáezGustavo Fuertessubject
Membrane proteinChemistryMembrane lipidsPeripheral membrane proteinMembrane fluiditylipids (amino acids peptides and proteins)Biological membraneLipid bilayerIntegral membrane proteinElasticity of cell membranesCell biologydescription
Bilayer lipids, far from being passive elements, have multiple roles in polypeptide-dependent pore formation. Lipids participate at all stages of the formation of pores by providing the binding site for proteins and peptides, conditioning their active structure and modulating the molecular reorganization of the membrane complex. Such general functions of lipids superimpose to other particular roles, from electrostatic and curvature effects to more specific actions in cases like cholesterol, sphingolipids or cardiolipin.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-01-01 |