6533b83afe1ef96bd12a7163

RESEARCH PRODUCT

Upgrading from iMac to iMicro

Alma N. MohebianyAri Waisman

subject

0301 basic medicineFetusMacrophagesCellular differentiationImmunologyCell DifferentiationBiologyCell biology03 medical and health sciencesFetus030104 developmental biologyInfectious Diseasesmedicine.anatomical_structureImmunityembryonic structuresImmunologymedicineHumansImmunology and AllergyYolk sacInduced pluripotent stem cellYolk Sac

description

In this issue of Immunity, Takata et al. (2017) describe a novel method to differentiate macrophages from iPSCs. These cells, which they call iMacs, are similar to yolk-sac-derived macrophages and are capable of undergoing terminal differentiation into tissue-resident-like macrophages in vitro and in vivo.

https://doi.org/10.1016/j.immuni.2017.07.001