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RESEARCH PRODUCT

The Positive Relationship between Moderate-to-Vigorous Physical Activity and Bone Mineral Content Is Not Mediated by Free Leptin Index in Prepubertal Children: The PANIC Study.

Annie M ConstableJosie E PorterDanielle BengerDimitris VlachopoulosAlan R BarkerSarah A MooreSonja SoininenEero A HaapalaKate WestgateSoren BrageRicardo R AgostineteRomulo A FernandesTimo A Lakka

subject

DXALeptinMalebone massgrowthluuRluuntiheyslapset (ikäryhmät)free leptin indexArticleprepubertal ageAbsorptiometry PhotonCross-Sectional StudiesBone DensityMedicineHumansleptiiniFemaleaccelerometeryChildhuman activitiesExercisefyysinen aktiivisuuschildhood

description

Purpose: Moderate-to-vigorous physical activity (MVPA) positively influences bone mineral content (BMC) in prepubertal children, but it is unknown whether this relationship is partially mediated by free leptin index. The aim of this study was to examine whether the relationship between MVPA and total body less head (TBLH) BMC is mediated or moderated by free leptin index in prepubertal children. Methods: We performed a cross-sectional analysis on 401 children (194 girls) from baseline examinations of the Physical Activity and Nutrition in Childhood Study. We applied the four-way decomposition mediation analysis method to assess whether free leptin index, measured from fasted blood samples, mediated the relationship between accelerometer-measured MVPA and TBLH BMC measured by dual-energy X-ray absorptiometry. Results: MVPA had a positive controlled direct effect on TBLH BMC in girls and boys (β = 0.010 to 0.011, p &lt

yearjournalcountryeditionlanguage
2021-05-18
https://www.repository.cam.ac.uk/handle/1810/323528