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RESEARCH PRODUCT
Anti-inflammatory properties of hydroalcoholic extracts of Argentine Puna plants
María Inés IslaMaría Inés IslaJosé Luis RíosRomina Torres CarroRosa M. GinerMaría Rosa AlbertoMaría Rosa Albertosubject
PUNA PLANT SPECIESNITRIC OXIDE SYNTHASEmedicine.drug_classProstaglandinBiologyAnti-inflammatoryNitric oxideCYCLOOXYGENASE-2Ciencias Biológicaschemistry.chemical_compoundmedicinechemistry.chemical_classificationTraditional medicinePROSTAGLANDINfungifood and beveragesBioquímica y Biología Molecularbiology.organism_classificationEnzyme assayNitric oxide synthaseEnzymechemistryBiochemistryToxicitybiology.proteinArtemia salinaNITRIC OXIDECIENCIAS NATURALES Y EXACTASFood Sciencedescription
The aim of this study is to evaluate the activity of thirteen hydroalcoholic extracts obtained from aerial parts of plants from Argentina Puna on pro-inflammatory enzymes and inflammatory mediators. Eleven extracts were non-cytotoxic on RAW 264.7. Data obtained suggest the capacity of these Argentine Puna plant extracts to inhibit the production of inflammatory mediators (nitric oxide and prostaglandin) at different levels. The plant extracts can affect enzymes expression and/or enzymes activity, and they can also act by NO scavenging. Each extract exerts its anti-inflammatory effect through different mechanisms. The inhibitory ability on pro-inflammatory enzymes by these hydroalcoholic extracts support their potential use as sources of natural anti-inflammatory agents. Moreover, all extracts were non-toxic on Artemia salina toxicity test. The consumption of dietary supplements prepared with these plant species could be used to prevent the development of chronic inflammatory pathologies. Fil: Torres Carro, Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Instituto de Quimica del Noroeste; Argentina Fil: Isla, Maria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Instituto de Quimica del Noroeste; Argentina. Universidad Nacional de Tucumán; Argentina Fil: Rios, Jose Luis. Universidad de Valencia; España Fil: Giner, Rosa Maria. Universidad de Valencia; España Fil: Alberto, Maria Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Instituto de Quimica del Noroeste; Argentina. Universidad Nacional de Tucumán; Argentina
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-01-01 | Food Research International |