6533b83afe1ef96bd12a78a5
RESEARCH PRODUCT
Synthesis of pillar[7]arene
De Rong CaoJian Long FuYu Hui KouHerbert MeierHong Qi TaoYu Chensubject
chemistry.chemical_compoundChemistryStereochemistryAcid catalyzedPillarGeneral ChemistryParaformaldehydeCondensation reactionMedicinal chemistryDemethylationCatalysisdescription
Abstract The first synthesis of pillar[7]arene is reported with two methods. Method A: the FeCl 3 -catalyzed condensation reaction of 1,4-dimethoxybenzene ( 1 ) with paraformaldehyde in CHCl 3 gave dimethoxypillar[7]arene ( 3 ). Method B: the p -toluenesulfonic acid catalyzed condensation reaction of 2,5-bis(benzyloxymethyl)-1,4-dimethoxybenzene ( 2 ) in CH 2 Cl 2 gave compound 3 . Demethylation of 3 with BBr 3 gave pillar[7]arene ( 4 ). The pillar[7]arene might be a perspective macrocyclic host in host–guest chemistry.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2012-05-01 | Chinese Chemical Letters |