6533b83afe1ef96bd12a7964

RESEARCH PRODUCT

IL-17 polarization of MAIT cells is derived from the activation of two different pathways

Diana Di LibertoMarianna Lo PizzoRiccardo AlessandroFrancesco DieliGiuliana GugginoLaura SaievaFrancesco CicciaGiovanni Triolo

subject

0301 basic medicineImmunologyStimulationInterleukin-23Mucosal-Associated Invariant T CellsSalivary GlandsSTAT303 medical and health sciencesIL-17; IL-23; IL-7; MAIT cells; RORc; Sjogren's Syndrome; STAT3; Immunology and Allergy; Immunology0302 clinical medicinestomatognathic systemDownregulation and upregulationRAR-related orphan receptor gammaIL-23Interleukin 23HumansImmunology and AllergySTAT3MAIT cellIL-7biologyInterleukin-17MAIT CellsCell biologyRORcIL-17Settore MED/16 - Reumatologia030104 developmental biologySjogren's Syndromebiology.proteinInterleukin 17030215 immunology

description

MAIT cells are expanded in salivary glands of patients with Sjogren's syndrome and are IL-17 polarized. IL-7 and IL-23 induce IL-17 production activating two different pathways: IL-7 stimulation induces in fact a significant STAT3 and HIF1alpha upregulation, conversely, IL-23 stimulation significantly induces RORc overexpression in MAIT cells of patients with Sjogren's syndrome.

yearjournalcountryeditionlanguage
2017-11-01
10.1002/eji.201747140http://hdl.handle.net/10447/245512