6533b83afe1ef96bd12a7b6e
RESEARCH PRODUCT
Interleukin 27 induces differentiation of neural C6-precursor cells into astrocytes.
Nina AdamStefan WirtzUlrike MayJürgen SchellerManuel KochStefanie KuhnsHauke DrechslerKirsten HattermannStefan Rose Johnsubject
B-LymphocytesInterleukin-6Interleukin-17BiophysicsInterleukinCell DifferentiationCell BiologyBiologyBiochemistryCell biologyCell LineInterleukin 33Astrocyte differentiationInterleukin 32MiceInterleukin 20AstrocytesImmunologyAnimalsInterleukin 27Molecular BiologyInterleukin 4Interleukin 3description
Interleukin 6 (IL6)-type cytokines are major regulators of inflammation and thereby contribute to the neuropathology and pathophysiology associated with inflammation of the central nervous system (CNS). Furthermore, astrocyte development which is a key process in the development of the CNS is also controlled by cytokines of the IL6-family. Interleukin 27 (IL27) is a recently identified member of this family and has been implicated in the inhibition of TH17 T-cell-responses. Here we show that IL27 and the HHV8 encoded viral IL6 (vIL6) induce C6 glioma cells to differentiate into an astrocyte-like state. Cytokine stimulation led to STAT-factor phosphorylation and consequently to protein expression of the astrocyte marker glial fibrillary acidic protein (GFAP). These data could be confirmed by GFAP-immunostaining of stimulated cells. Taken together, IL27 and vIL6 can be considered as new astrocyte-inducing cytokines of the brain.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2007-12-01 | Biochemical and biophysical research communications |