6533b850fe1ef96bd12a826f
RESEARCH PRODUCT
A Trisialoganglioside Containing a Sialyl α2-6 N-Acetylgalactosamine Residue Is a Cholinergic-Specific Antigen, Chol-1α1
Susumu AndoYoshio HirabayashiKazuo KonFuyuhiko InagakiKiyohide KojimaShin-ichi TateVictor P. Whittakersubject
AntiserumGangliosidetechnology industry and agricultureGeneral MedicineBiologyBiochemistryN-AcetylgalactosamineSialic acidchemistry.chemical_compoundResidue (chemistry)chemistryAntigenBiochemistryGalactosepolycyclic compoundsCholinergiclipids (amino acids peptides and proteins)Molecular Biologydescription
Cholinergic-specific antigens termed the Chol-1 family have been suggested to be of a ganglioside nature by Richardson et al. (J. Neurochem. 38, 1605-1614, 1982). Two molecular species of polysialogangliosides among bovine brain gangliosides were found to react with anti-Chol-1 alpha antiserum. One of them, Chol-1 alpha-a, was isolated and characterized as a trisialoganglioside containing the gangliotetraose backbone in which 1 mol of sialic acid was attached to each of the reducing end galactose, N-acetylgalactosamine and internal galactose residues, respectively. The chemical structure of Chol-1 alpha-a was determined for the first time, being as follows: IV3NeuAc III6NeuAc II3NeuAc-GgOse4 Cer.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1992-03-01 | The Journal of Biochemistry |