6533b850fe1ef96bd12a8309
RESEARCH PRODUCT
Superfood for axons: Glial exosomes boost axonal energetics by delivery of SIRT2
Eva-maria Krämer-alberssubject
medicine.anatomical_structurenervous systemChemistryGeneral NeurosciencemedicineNeuronAxonSIRT2Extracellular vesiclesMitochondrial proteinEnergy homeostasisMicrovesiclesCell biologydescription
Axon integrity depends on support by glia facilitating axonal maintenance and energy homeostasis, but the molecular mechanisms are not well understood. In this issue of Neuron, Chamberlain et al. (2021) provide evidence that oligodendrocyte-to-axon transfer of SIRT2 via extracellular vesicles (exosomes) enables deacetylation of mitochondrial proteins, enhancing axonal energy production.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-11-01 | Neuron |