BDNF as a Mediator of Antidepressant Response: Recent Advances and Lifestyle Interactions

6533b850fe1ef96bd12a83de

RESEARCH PRODUCT

BDNF as a Mediator of Antidepressant Response: Recent Advances and Lifestyle Interactions

Susana Cubillos Olivia Engmann Anna Ebrancato

subject

antidepressant Brain-Derived Neurotrophic Factor Organic Chemistry TrkB General Medicine Antidepressive Agents Catalysis Computer Science Applications Inorganic Chemistry BDNF depression Settore BIO/14 - Farmacologia Physical and Theoretical Chemistry Molecular Biology environment Spectroscopy Signal Transduction

description

Conventional antidepressants are widely employed in several psychiatric and neurologic disorders, yet the mechanisms underlying their delayed and partial therapeutic effects are only gradually being understood. This narrative review provides an up-to-date overview of the interplay between antidepressant treatment and Brain-Derived Neurotrophic Factor (BDNF) signaling. In addition, the impact of nutritional, environmental and physiological factors on BDNF and the antidepressant response is outlined. This review underlines the necessity to include information on lifestyle choices in testing and developing antidepressant treatments in the future.

year	journal	country	edition	language
2022-10-12

10.3390/ijms232214445 https://hdl.handle.net/10447/574070

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