6533b850fe1ef96bd12a840b
RESEARCH PRODUCT
Palladium-catalyzed dehydrogenative β'-functionalization of β-keto esters with indoles at room temperature.
Mikko V. LeskinenKai-tai YipPetri M. PihkoArto Valkonensubject
Indole testColloid and Surface Chemistrychemistrychemistry.chemical_elementSurface modificationOrganic chemistryGeneral Chemistryta116BiochemistryCatalysisPalladiumCatalysisdescription
The dehydrogenative β′-functionalization of α-substituted β-keto esters with indoles proceeds with high regioselectivities (C3-selective for the indole partner and β′-selective for the β-keto ester) and good yields under mild palladium catalysis at room temperature with a variety of oxidants. Two possible mechanisms involving either late or early involvement of indole are presented.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2012-03-23 | Journal of the American Chemical Society |