6533b850fe1ef96bd12a85f1
RESEARCH PRODUCT
Hyaluronan-coated polybenzofulvene brushes as biomimetic materials
Germano GiulianiAlessandro DonatiFrancesco MakovecGiorgio GrisciFilippo SamperiClaudia BonechiAndrea CappelliRaniero MendichiMariano LicciardiMarco PaolinoVincenzo RazzanoGaetano GiammonaSalvatore BattiatoCinzia Scialabbasubject
polymer brushPolymers and PlasticsHyaluronic acidBiomedical EngineeringBioengineering02 engineering and technology010402 general chemistryPolymer brush01 natural sciencesBiochemistrychemistry.chemical_compoundHyaluronic acidPolymer chemistryZeta potentialCell adhesionPolymers and PlasticbiologyCD44polybenzofulveneOrganic Chemistry021001 nanoscience & nanotechnology0104 chemical scienceschemistrySettore CHIM/09 - Farmaceutico Tecnologico ApplicativoDrug deliverybiology.proteinBiophysics0210 nano-technologyEthylene glycolMacromoleculedescription
Hyaluronic acid (HA) forms pericellular coats in many cell types that are involved in the early stages of cell adhesion by interacting with the CD44 receptor. Based on the largely recognized overexpression of the CD44 receptor in tumor tissues, a polybenzofulvene molecular brush has been enveloped into hyaluronan shells to obtain a tri-component polymer brush (TCPB) composed of intrinsically fluorescent backbones bearing nona(ethylene glycol) arms terminated with low molecular weight HA macromolecules. The nanoaggregates obtained in TCPB water dispersions were characterized on the basis of dimensions, zeta potential, and in vitro cell toxicity. This biomimetic multifunctional material bearing HA on the surface of its cylindrical brush architecture showed promising prerequisites for the preparation of nanostructured drug delivery systems.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-01-01 |