6533b851fe1ef96bd12a8c54

RESEARCH PRODUCT

Synthesis of a bridgehead nitrogen system. Imidazo[1,5-b]pyridazine derivatives

Salvatore PetrusoVincenzo SprioOnofrio Migliara

subject

Pyridazinechemistry.chemical_compoundchemistryOrganic ChemistryIntramolecular cyclizationOrganic chemistrychemistry.chemical_elementMedicinal chemistryNitrogen

description

3,4-Dibenzoyl-2-oxobutyrate 4-semicarbazone (6a), ethyl 2,4-dioxo-3-phenacylvalerate 3-semicarbazone (6b) and diethyl phenacyloxalectate 3-semicarbazone (6c) via acid catalysed intramolecular cyclization afforded 2-phenyl-4-R-3H-imidazo[1,5-d]pyridazine-5,7-(6H)diones (8d,e,f). Elemental analyses and spectroscopic data (ir, nmr, ms) were in good agreement with the assigned structures.

yearjournalcountryeditionlanguage
1979-09-01Journal of Heterocyclic Chemistry
https://doi.org/10.1002/jhet.5570160605