6533b851fe1ef96bd12a8de9

RESEARCH PRODUCT

Transcriptome of early embryonic invasion at implantation sites in a murine model

S. Martinez-escribanoSergio OehningerSergio OehningerJ. A. Martínez-conejeroSilvina BoccaN. A. FranchiN. A. FranchiN. A. FranchiJuan Manuel Moreno-moyaJosé A. HorcajadasJosé A. Horcajadas

subject

0301 basic medicineDECIDUAL TISSUEECTOPLACENTAL CONEOtras Ciencias BiológicasReproductive technologyBiologyMOUSE IMPLANTATIONTROPHOBLAST INVASIONCiencias BiológicasTranscriptome03 medical and health sciences0302 clinical medicineEndocrinologyMICROARRAYGeneticsmedicineCompartment (development)Molecular Biology030219 obstetrics & reproductive medicineMicroarray analysis techniquesDeciduaEmbryogenesisEmbryonic TissueEmbryonic stem cellCell biology030104 developmental biologymedicine.anatomical_structureRNA EXPRESSION PATTERNSReproductive Medicineembryonic structuresImmunologyAnimal Science and ZoologyCIENCIAS NATURALES Y EXACTASDevelopmental BiologyBiotechnology

description

Successful implantation relies on the interaction between a competent embryo and a receptive endometrium. The aim of the present study was to investigate genes differentially expressed in early invasive embryonic tissue versus decidual tissue in mice. Samples were obtained from the ectoplacental cone, the immediately surrounding deciduas and from deciduas from interimplantation sites. Microarray analysis showed that 817 genes were differentially expressed between extra-embryonic tissue and the surrounding decidua and that 360 genes were differentially expressed between the different deciduas, with a high representation of developmental processes. Genes differentially expressed in the maternal compartment included chemokines, lipoproteins, growth factors and transcription factors, whereas the embryonic invasive tissue expressed genes commonly observed in invasive tumour-like processes. These results provide information about genes involved in early embryonic invasion and the control exerted by the surrounding decidua. This information may be useful to find targets involved in pathologies associated with implantation failure and early pregnancy loss. Fil: Moreno Moya, J. M.. Universidad de Valencia; España Fil: Franchi, Nilda Anahi. Eastern Virginia Medical School; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina Fil: Martínez Escribano, S.. Universidad de Valencia; España Fil: Martínez Conejero, J. A.. Universidad de Valencia; España Fil: Bocca, S.. Eastern Virginia Medical School; Estados Unidos Fil: Oehninger, S.. Eastern Virginia Medical School; Estados Unidos Fil: Horcajadas, J. A.. Unviersidad Pablo de Olavide; España

yearjournalcountryeditionlanguage
2015-05-01Reproduction, Fertility and Development
https://doi.org/10.1071/rd14166