6533b851fe1ef96bd12a8df3
RESEARCH PRODUCT
Epidemiology and outcomes of hospital-acquired bloodstream infections in intensive care unit patients: the EUROBACT-2 international cohort study.
Mahboobeh RashidiHytham K S HamidElfayadh SaidahmedAli Adil Ali KararMelanie Mc CreeFowotade AdeolaOlusola IdowuMotunrayo OladimejiGabriel AsiyanbiIbironke DesaluJohn O OlatosiEuphemia Mgbosoro UgwuSaidu Yusuf YakubuKrushna Chandra MisraKaladhar SheshalaSudipta MukherjeePralay GhoshJagadish ChandranCarol DsilvaSailaja K BabyM K RenukaMayur PatelDarshana RathodAvijatri DattaPayel BoseSuhail Sarwar SiddiquiAhmad OzairSyed Nabeel MuzaffarSaurav ShekharRitu SinghMadhumati PahujaNikhilesh JainNoor Ahmedi RubinaR VaidyanathanPratit SamdaniJanardan NimbolkarPriya SharmaSaurabh KarmakarAnkur SharmaNikhil KothariArvind BaroniaMohan GurjarMohammad Motiul IslamRajib HasanShihan Mahmud Redwanul HuqRaihan RabbaniTayne HewerPatricia ThompsonWendy SliglDemetrios J KutsogiannisLorena MccoshenNadia BaigWendy SliglYaroslava BurmaAnton SokhanPaul Jean RenaudMiss Sally K HumphreysRebecca E TilleyJamie PatelBen AttwoodMoses ChikungwaMatthew JacksonAhmed ZakiDorota BanachValentina Della TorreNicholas MarsdenSupriya AntrolikarSanthana KannanRachel MckeePeter McguiganR Rao BaikadyS JhanjiE BlackA HusainS LoftusKate TathamDaniel HallRebecca LongbottomTom BaumerTamas SzakmanyAshraf RoshdyAmanda SandersonJenny RitzemaAllison KeeganJaroslav CermanClive GrahamTim SmithStephen ColeKatherine CobbBenjamin J ParcellHollie AngellKeith HugillUwe FrankeSonia Sousa AriasMaie TempletonJames LennardCaroline MacfieAimee JohnsonRachael DolanAimee YonanMarina SoltanManan BajajShraddha GoyalRandeep MulhiTomasz TorlinskiReena KhadeGeorge TinaslanidisArtemis ZormpaAshok RajMelanie KentAmanda CowtonMaria FaulknerKate TizardRoceld RojoDavid AntcliffeAri ErcoleAndrew Conway MorrisMatthew RoutledgeAndrew Conway MorrisSabahat Cagan AktasAyse BatirelAhmet AkyolSenay GoksuYasemin ErsoyYasar BayindirNilgün AltinYunus GürbüzCem ErdoğanCansu OzgenHulya SungurtekinGuliz EvikGulden ErsozSeda GuzeldagYeliz BilirKemal Tolga SaracogluAhmet ErogluFirdevs AksoyIftihar KoksalRidvan KaraaliNese SaltogluRumeysa CakmakBurcu TunayMesut YilmazOzlem O AkdoganNurcan N BaykamOnur ÇOlakCanan AgalarAli SariKürşat GundoganTürkay AkbasSait ÇOlakEmine Kubra Dindar DemirayÇIğdem ErolBarcin OzturkMurat TelliIbrahim KurtAyşe Kaya KalemBircan KayaaslanLeyla TalanNeriman Defne AltintasSolakoğlu CeyhunSelcuk MehtapHulya KusogluSesin KocagozArif TimurogluAbdullah Tarik AslanMurat AkovaS Abed-maillardJl PaganiStephan JakobJosef PrazakLina De GeerJoyce ÅKerlundAlicia EdinMichael HaneyCarl Johan SvenssonDzana SpahicFredrik SjövallAlberto Orejas GallegoMiguel Angel Blasco-navalpotroMariana NovoJ Ignacio AyestaranAlejandro Suarez De La RicaEmilio MasedaDra M RodriguezDra Mj AsensioEmilio Garcia PrietoLorena Forcelledo EspinaDra Maria SalgadoAlejandro UbedaGemma GomàEmilio Diaz SantosMaría Dolores QuesadaLaura RaguerRegina RoigBeatriz CatalanFernando ArmestarRosana Munoz BermudezMaria Pilar Gracia ArnillasJoaquin Amador AmerigoMatias FloresPaula VeraVanessa CasaresMaria MartinezRicard Ferrer RoccaMikhail FurmanVladislav BelskiyMaria ChukinaNatala VistovskayaAleksandr EremenkoDenis GaigolnikMaksim TribulevNadezhda ZubarevaMarat MagomedovYulia MeleshkinaAnastasia AnderzhanovaAlexey GritsanOlguta LunguIoana GrigorasAlexandra MarcuMihai PopescuDana TomescuCornelia Elena PredoiDaniela Carmen FilipescuCristian CobilinschiIoana Marina GrintescuSerban Bubenek-turconiLiana ValeanuAntónio Carvalho MendesÉNio PereiraJosé Pedro MouraCristina NunesDulce PascoalinhoJoana QueiróSara LedoTito Da CostaElena MolinosRui Pedro CunhaVasco CostaTiago DuarteIsabel BotelhoAntónio Manuel Pereira De FigueiredoAna TeresaAndriy KrystopchukAna Rios PintoAna Josefina Pinheiro MarquesMadalena AlvesNádia GuimarãesTiago PereiraNuno CartozeAlessandra BisantiIgnacio Martin-loechesIwona Pietraszek-grzywaczewskaMariusz PeichotaHanna BrodaTomasz NowakowskiDominika WasowskaPaulina Walczak-wieteskaAnna KotkowskaJozef BojkoAnna SzczesniakIrmina Kaptur KomorowskaBarbara TamowiczAdam MikstackiAnna Chiara RizzoAntonella CotoiaSilvia FiorelliMonica RoccoMarco CovottaLorella PelagalliAndrea Di GuardoDavide BellinaMariachiara IppolitoAndrea CortegianiDenise BattagliniPaolo PelosiMaria Grazia SchleveninFrancesco ZuccaroGiovanni LodiIvan DarouiMichele MirabellaElisa PorcileAngelo GratarolaDaniele Roberto GiacobbeValentina Di GravioJoel VargasSimone CarelliLuca Maria MontiniGennaro De PascaleGabriele SalesGiorgia MontrucchioGeorgios PapathanakosVasilios KouroulasIoannis RetselasVasiliki TheodorouDiamantina MarouliPolychronis MalliotakisMariota Panagiota AlmiroudiGeorges DimopoulosFadi AliEirini PapageorgiouZoi AthanasaAikaterini SakagianniVasiliki ChantziaraAnna EfthymiouMaria GeorgopoulouMarinos ChatzisAnastasios SakkalisCharikleia NikolaouEvangelos KogkopoulosMarina OikonomouC KampolisM PapanikolaouKyriaki MarmanidouHarry PaskalisIlias KaraiskosLeora MoldovanMariana Kristina MateiVasiliki KoutsoukouVasiliki RomanouMaria VasileiouFoteini RentaSofia PapotiCristina IasonidouEvangelos KaimakamisVasiliki SoulountsiGeorgios FildisisVasiliki PsallidaDimitrios SmyrniotisKostoula ArvanitiTalgat TemirovYevgeniy MerenkovBaurzhan BabashevZhannur KaligozhinYelena BazhykayevaMiras MugazovYerlan YmbetzhanovDmitriy VidermanCarlos MetzPhilippe LepperCarola WempeAntje GottschalkKarsten SchmidtSimon DublerBastian PasiekaSirak PetrosDaniel Thomas-rueddelFrank BloosSandra HoheisenHendrik BrachtKada KloucheNadia ImziClaire Dahyot-fizelierMuriel FartoukhGuillaume VoiriotChristelle AparicioShidasp SiamiLoïc Le GuennecSophie DemeretStein SilvaBenjamine SartonClaire RogerJean-yves LefrantRomaric LarcherGaëtan BadrePierre KalfonKeyvan RazaziArmand Mekonted DessapThomas BaudryLaurent ArgaudRoland SmonigGuillaume LouisJérémy BourenneMarc GainnierFrançois BarbierFlora DjanikianPierre-françois PerrigaultArnaud FoucrierSylvie JannyEmmanuel WeissCédric BruelMarc TranFrançois PhilippartRémi PauletMartial ThyraultMatthieu DupreyPierre GarconJean-paul MiraMathieu Le SouhaitierPerrine BortolottiEric KipnisThibault DuburcqElisabeth CoupezBertrand SouweineAlexandru NicaSerge AlfandariOlivier LeroyJérémy RosmanPhilippe MateuEtienne EscudierCharlotte GuesdonAlexandre MassriM BeuzelinA MarchalotAnthony Le MeurJohann AuchabieJérémy CastaneraThierry DulacP MontraversN ZappelaJuliette PatrierJean-françois TimsitCharlotte ArbelotMarc LeoneHrvoje LasicMario NikolicSanja SakanJasminka PersecAna Vujaklija BrajkovicRadovan RadonicIna Filipovic-grcicAida CustovicBiljana ZlojutroPedja KovacevicGodelive OpdenackerElisabeth De WaeleXavier WitteboleNicolas SerckNicolas De SchryverBenoît MissetNathalie LayosCindérella NoelPatrick BistonLionel HaentjensPierre HeninJean-baptiste MeslandSofie F M VanderhaeghenMarc BourgeoisWouter DenysIsabelle HollevoetJan De WaeleLiesbet De BusErnesto Deloya TomasOrlando R Perez-nietoBrigitte Tejeda-huezoLuis Sánchez-hurtadoSilvio A ÑAmendys-silvaAdrian Davalos-alvarezJose G Dominguez-cheritManuel Lomeli-teranMissael Vladimir Espinoza VillafuerteMara Ocotlan Gonzalez HerreraCandy Garcia AguilarJesús Nicolás Pantoja LealRoberto Alejandro CastilloMariana HermosilloJuan P Romero-gonzalezSilvio A ÑAmendys-silvaLuis Felipe ReyesLuis Felipe ReyesPablo MontefioreYanina NuccetelliMicrobiologa Irene AlonzoDra Marta AparicioMatías SeguraRubén FernándezPatricia Mabel LopezJosé Oscar AcevedoLic Natalia MorvilloPablo CentenoWalid SellamiOlfa TurkiMounir BouazizLubna BakrMohammad Al-jadaanNatalia Abu-sayfMohammad Karam ChaabanAhmed AljabbaryMaher AwadGhaleb A AlmekhlafiOmar ElrabiHend SallamShaikh NissarMarcus LanceEdin KaricAbdurahaman ElbuzidiAli Ait HssainMustafa Abu JayyabSarah AmroZ BelkhadirA GhannamAbdelhamid HachimiOujidi YounesBrahim HousniAmine Ali ZeggwaghTarek DendaneMaazouzi Ahmed WajdiDoumiri MouhssineNabil KanjaaBrahim BoukattaRachid SeddikiIssam SerghiniRabab Shaban Ben HasanHayat Ben HasanRania JobranAisha Khaled HdadaFathi A AbousninaEman AbdulwahedAhmed Sa TaherAhmad BouhuwaishHala BilkhayrBushray AlmiqlashAhmed Gaber Sadik HomaidanAlmajdoub Mohammed AlialiAhmed AqeelahMarwa GamraAhmad BuimsaedahAya FaresRebecca IbrahimFayez AbilamaAdei DiabBelal HararaPhillip LevinDaniel BelmanMerav RiglerIlya KaganPierre SingerAbdullah Khudhur AhmedSeyed Mohammad Nasirodin TabatabaeiRamin TajvidiMansoor MasjediHakimeh SarshadGolnar SabetianGholamreza DabiriFatemeh AalinezhadAta MahmoodpoorMohammad Amin ZargarArash KianiFereshteh AmiriFatemeh JavaherforooshReza BaghbanianFarhad SoltaniMohsen SavaieFatemeh AhmadiDavood KashipazhaZahra MehrabanSeyed Hamid BorsiMaryam OuhadianFarid ZandHanan M HemeadAhmed K AwadMerihan A ElbadawyAhmed ElsayedOmar ElmandouhAmer AldhaliaAhmed SaberMohamed ElbahnasawyTarek MostafaNermin OsmanMina BarsoumAmr ElhadidyAdel AlsisiAshraf El HoufiRashid NadeemSupattra ChiewroongrojYutthana ApichatbutrPhunsup WongsurakiatShih-chi KuLi-kuo KuoTing-yu HuCong-tat CiaNai-kuan ChouYu Chang YehLouis Xiang Long NgKangqi NgJessica Lishan QuahJia Yan LimCaroline Yu Ming OngAndrew Yunkai LiKen Junyang GohAndrea Lay Hoon KwaSui An LieShin Yi NgQing Yuan GohSung Yoon LimSeung Yong ParkSunghoon ParkSang-min LeeKyeongman JeonSaedah AliMohd Zulfakar MazlanAbd Hamid AzmanLee Kok TongZuraini Md NoorHamizah Bt Abdul RahmanKean Khang FongSiong Ling Danny WongMun Thing LiewSheshendrasurian VisvalingamLee See PhengMuhamad Fadhil Hadi JamaluddinM Shahnaz HasanShunsuke TakakiHideaki KatoKaori AtobeHiroki SaitoHiroshi RinkaKoichiro OmoriShigeki FujitaniHideki YoshidaMichio NagashimaYuka MishimaHidenobu ShigemitsuAkira KuriyamaTakeo MatsuyoshiJun MakinoKoji HosokawaSatoru HashimotoMasaki YamasakiToshiyuki KarumaiYoshiro HayashiNan GengLi PeijeXie WeifengLing YeBingyu QinYan WangJing YanMin HuangSuming ZhouChungfang HuJilu YeMin ZhangYongjie YinJinfeng WangRuilan WangChengfen YinLei XuChen MingminQiu WusiJuan ZhaoPeng ZhaoHao WangXiaomei ChenJili LuoChuanyun QianWang ZhenLu Wei-huaXie JianfengQiu HaiboDhadappa Damodar SridharanShah SudhirchandraP Dhakshina MoorthiTomas MonHaji Adi Muhamad Ibnu WalidAlexis TabahNiccolò BuettiQuentin StaiqulyStéphane RucklyMurat AkovaAbdullah Tarik AslanMarc LeoneAndrew Conway MorrisMatteo BassettiKostoula ArvanitiJeffrey LipmanRicard FerrerHaibo QiuJosé-artur PaivaPedro PovoaLiesbet De BusJan De WaeleFarid ZandMohan GurjarAdel AlsisiKhalid AbidiHendrik BrachtYoshiro HayashiKyeongman JeonMuhammed ElhadiFrançois BarbierJean-françois TimsitAlexis TabahHamish PollockBen MargettsMeredith YoungNeeraj BhadangeSteven TylerAnne LedtischkeMackenzie FinnisAnne LedtischkeMackenzie FinnisJyotsna DwivediManoj SaxenaVishwanath BiradarNatalie SoarVineet SarodeDavid BrewsterAdrian RegliElizabeth WeedaSamiul AhmedCheryl FourieKevin LauplandMahesh RamananJames WalshamJason MeyerEdward LittonAnna Maria PalermoTimothy YapEge ErogluAntony George AttokaranC'havala JaramilloKhalid Mahmood Khan NafeesNurhikmahtul Aqilah Haji Abd Rashidsubject
antibiotic resistancebloodstream infectionhospital-acquiredbacteremiaCritical Care and Intensive Care Medicineantibiotic resistance ; bacteremia ; bloodstream infection ; hospital-acquired.description
Purpose: In the critically ill, hospital-acquired bloodstream infections (HA-BSI) are associated with significant mortality. Granular data are required for optimizing management, and developing guidelines and clinical trials. Methods: We carried out a prospective international cohort study of adult patients (≥ 18 years of age) with HA-BSI treated in intensive care units (ICUs) between June 2019 and February 2021. Results: 2600 patients from 333 ICUs in 52 countries were included. 78% HA-BSI were ICU-acquired. Median Sequential Organ Failure Assessment (SOFA) score was 8 [IQR 5; 11] at HA-BSI diagnosis. Most frequent sources of infection included pneumonia (26.7%) and intravascular catheters (26.4%). Most frequent pathogens were Gram-negative bacteria (59.0%), predominantly Klebsiella spp. (27.9%), Acinetobacter spp. (20.3%), Escherichia coli (15.8%), and Pseudomonas spp. (14.3%). Carbapenem resistance was present in 37.8%, 84.6%, 7.4%, and 33.2%, respectively. Difficult-to-treat resistance (DTR) was present in 23.5% and pan-drug resistance in 1.5%. Antimicrobial therapy was deemed adequate within 24 h for 51.5%. Antimicrobial resistance was associated with longer delays to adequate antimicrobial therapy. Source control was needed in 52.5% but not achieved in 18.2%. Mortality was 37.1%, and only 16.1% had been discharged alive from hospital by day-28. Conclusions: HA-BSI was frequently caused by Gram-negative, carbapenem-resistant and DTR pathogens. Antimicrobial resistance led to delays in adequate antimicrobial therapy. Mortality was high, and at day-28 only a minority of the patients were discharged alive from the hospital. Prevention of antimicrobial resistance and focusing on adequate antimicrobial therapy and source control are important to optimize patient management and outcomes.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2023-02-10 |