6533b851fe1ef96bd12a8e64
RESEARCH PRODUCT
Recent developments and applications of the chiral Brønsted acid catalyzed allylboration of carbonyl compounds
Santos FusteroDaniel M. SedgwickMatthew N. GraysonPablo Barriosubject
enantioselective catalysis010405 organic chemistryChemistryOrganic Chemistryasymmetric synthesisEnantioselective synthesis010402 general chemistryDFT calculations01 natural sciencesCombinatorial chemistryCatalysis0104 chemical sciencesCatalysishomoallylic alcoholsallylborationchiral Brønsted acidsBrønsted–Lowry acid–base theoryenantioselective catalysischiral BrOnsted acidsdescription
The 50-year-old allylboration reaction has seen dramatic developments since the dawn of the new century after the first catalytic asymmetric versions came into play. In the past decade alone, several methodologies capable of achieving the desired homoallylic alcohols in over 90% ee have been developed. This review focuses on the chiral Brønsted acid catalyzed allylboration reaction, covering everything from the very first examples and precedents to modern day variations and applications.1 Introduction2 Early Developments3 Synthetic Applications4 Variants5 Computational Contribution6 Conclusions
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-01-01 |