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RESEARCH PRODUCT

Cytotoxic Activity and Composition of Petroleum Ether Extract from Magydaris tomentosa (Desf.) W. D. J. Koch (Apiaceae)

Mariem Ben JemiaMaurizio BrunoGiuseppina AutoreSergio RosselliStefania MarzoccoCarmen FormisanoFelice Senatore

subject

AlkanePharmaceutical ScienceAnalytical ChemistryMicechemistry.chemical_compoundxanthotoxinDrug DiscoveryCytotoxic T cellPetroleum etherSettore BIO/15 - Biologia FarmaceuticaCell DeathbiologyTraditional medicineisopimpinellinxanthotoxolFlowerChemistry (miscellaneous)Molecular MedicineHumanIsopimpinellinFlowersCoumarinMagydaris tomentosaGas Chromatography-Mass SpectrometryArticlePlant Extractfuranocoumarinslcsh:QD241-441<i>Magydaris tomentosa</i>ostholelcsh:Organic chemistryCell Line TumorFuranocoumarinAlkanesBotanyAnimalsHumansPhysical and Theoretical Chemistryether extractMagydaris tomentosa; coumarins; furanocoumarins; xanthotoxin; xanthotoxol; isopimpinellin; osthole; bergaptene; MCF-7Cell ProliferationApiaceaecoumarinsAnimalPlant ExtractsOrganic ChemistrySettore CHIM/06 - Chimica Organicabiology.organism_classificationCoumarinIn vitrochemistryMCF-7XanthotoxolMCF-7Apiaceaebergaptene

description

The petroleum ether extract of Magydaris tomentosa flowers (Desf.) W. D. J. Koch has been analyzed by GC-MS. It is mainly constituted by furanocoumarins such as xanthotoxin, xanthotoxol, isopimpinellin, and bergaptene. Other coumarins such as 7-methoxy-8-(2-formyl-2-methylpropyl) coumarin and osthole also occurred. The antiproliferative activity of Magydaris tomentosa flower extract has been evaluated in vitro on murine monocye/macrophages (J774A.1), human melanoma (A375) and human breast cancer (MCF-7) tumor cell lines, showing a major activity against the latter.

yearjournalcountryeditionlanguage
2015-01-16Molecules
10.3390/molecules20011571http://dx.doi.org/10.3390/molecules20011571