6533b851fe1ef96bd12a96e8

RESEARCH PRODUCT

Drosophila melanogaster overexpression FAS live longer

Consuelo BorrásJorge Sanz-rosVladimir I. KlichkoLucia Gimeno-mallenchJose ViñaJuan GambiniCristina Mas BarguesSvetlana N. RadyukMar DromantWilliam C. OrrMarta Inglés

subject

biologymedia_common.quotation_subjectLongevitybiology.organism_classificationFas receptorBiochemistryFas ligandPeripheral bloodCell biologyTranscriptomeApoptosisPhysiology (medical)Drosophila melanogasterGenemedia_common

description

FAS and FAS ligand is critical in the control of the extension of extrinsic pathway of apoptosis. In previous studies we have performed transcriptomics peripheral blood cells from centenarians, octogenarians and young persons and we found over expression in centenarians of the FAS receptor. To confirm the role of FAS ligand in longevity across animal species, we have generated Drosophila melanogaster that over expresses this gene using the GAL4-UAS technique. The results show that flies overexpressing FAS increase maximal longevity in twelve percent and average longevity in six percent. Therefore, we confirm that FAS is related to longevity flight.

yearjournalcountryeditionlanguage
2018-05-01Free Radical Biology and Medicine
https://doi.org/10.1016/j.freeradbiomed.2018.04.380