6533b851fe1ef96bd12a97dc

RESEARCH PRODUCT

Massive digoxin intoxication in childhood.

B. K. JüngstW. GemppGilfrich HjH. Stopfkuchen

subject

MaleDigoxinInjury controlAccident preventionPhysiologyPoison controlSuicide AttemptedCritical Care and Intensive Care MedicineDigitalis levelElectrocardiographypolycyclic compoundsMedicineHumanscardiovascular diseasesChildbusiness.industrydigestive oral and skin physiologySerum digoxin levelcarbohydrates (lipids)Heart BlockAnesthesiaPhenytoinPotassiumDigoxin intoxicationbusinessSerum potassium level

description

In a 10 year old boy 8 hours after taking about 16 mg beta-acetyl-digoxin a maximum serum digoxin level of 31.8 ng/ml was measured radioimmunologically. This is the highest digitalis level in childhood described to date. The serum potassium level rose to 7.4 mmol/l. Complete atrio-ventricular block, and salves of ventricular premature beats were the most serious rhythm disturbances. The absence of life threatening rhythm disturbances is attributed to the early use of diphenylhydantoin in small frequent doses.

yearjournalcountryeditionlanguage
1978-12-01Intensive care medicine
10.1007/bf01902547https://pubmed.ncbi.nlm.nih.gov/739078