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RESEARCH PRODUCT
Unprecedented intermolecular transamidation reaction of N-carbamoylmethyl-N'-tosylguanidines.
Jamal LasriJosé Sepúlveda-arquesMaria Eugenia González-rosendesubject
chemistry.chemical_compoundPrimary (chemistry)TosylchemistryOrganic ChemistryIntermolecular forceOrganic chemistryPhysical and Theoretical ChemistryGuanidineBiochemistryMedicinal chemistrydescription
[reaction: see text] N-Carbamoylmethyl-N'-tosyl guanidine 2 reacts easily with primary alkylamines to afford substituted carboxamides 3. The reaction proceeds via a five-membered-ring intermediate 5, which could be isolated, and features a rare example of an intermolecular transamidation reaction under mild conditions.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2003-10-11 | Organic letters |