1,4-dihidropiridīna AV-153-Na mijiedarbības ar DNS molekulu izvērtējums šūnas ietvaros

6533b851fe1ef96bd12a9c9d

RESEARCH PRODUCT

1,4-dihidropiridīna AV-153-Na mijiedarbības ar DNS molekulu izvērtējums šūnas ietvaros

subject

konfokālā mikroskopija AV-153-Na šūna 1 4-dihidropiridīni DNS molekula Farmācija

description

AV-153-Na ir 1,4-DHP analogs ar antimutagēnām un DNS pasargājošām īpašībām, kas spēj mijiedarboties ar DNS molekulu caur interkalāciju. Maģistra darba mērķis bija izvērtēt AV-153-Na spēju iekļūt šūnā un vizualizēt tā iespējamo mijiedarbību ar DNS molekulu. Rezultāti parādīja, ka AV-153-Na spēj nokļūt šūnā. AV-153-Na flluorescence tika vizualizēta gan dzīvās, gan fiksētās šūnās. Fluorescence tika konstatēta gan šūnu citoplazmā, gan šūnu kodolos. Pētāmā 1,4-DHP mijiedarbība ar DNS halo netika vizualizēta, tomēr pēc apstrādes ar koncentrētu sāļu šķīdumu fluorecence saglabājas tikai šūnu kodolu apvalku rajonā. Apkopojot iegūtos rezultātus un jau publicētos datus secinām, ka AV-153-Na mijiedarbojās ar DNS molekulu un ietekmē procesus šūnā ļoti zemās koncentrācijās, kuras ar izmantotām mikroskopijas metodēm nav iespējams vizualizēt.

year	journal	country	edition	language
2016-01-01

https://dspace.lu.lv/dspace/handle/7/32823

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