Metformīna ietekme uz Alcheimera slimības modeļa žurku sociālo uzvedību

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RESEARCH PRODUCT

Metformīna ietekme uz Alcheimera slimības modeļa žurku sociālo uzvedību

subject

metformīns demence sociabilitāte Alcheimera slimība streptozotocīns Farmācija

description

Šī darba mērķis bija noskaidrot pretdiabēta līdzekļa metformīna radītos efektus Alcheimera slimības (AD) streptozotocīna (STZ) modeļa žurkām sociālās uzvedības testā. Iegūtie rezultāti rāda, ka metformīns gan devā 75 mg/kg, gan 100 mg/kg būtiski uzlaboja AD modeļa žurku sociālo interesi un īstermiņa atmiņu. Iegūtie dati liecina, ka metformīns spēj uzlabot AD STZ modeļa žurku interesi par nepazīstamu dzīvnieku un rosināt sociālo kontaktu. Tomēr nepieciešami tālāki pētījumi, lai noteiktu metformīna sociabilitāti veicinošus celulāros un molekulāros mehānismus.

year	journal	country	edition	language
2019-01-01

https://dspace.lu.lv/dspace/handle/7/48701

PEPhysical Sciences and Engineering
- PE2Fundamental Constituents of Matter
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  - PE2_2 Phenomenology of fundamental interactions
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  - PE2_10Atomic, molecular physics
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  - PE2_14Lasers, ultra-short lasers and laser physics
  - PE2_17Metrology and measurement
  - PE2_16Non-linear physics
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- PE1Mathematics
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SHSocial Sciences and Humanities
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