6533b852fe1ef96bd12aaa54
RESEARCH PRODUCT
Polyphosphate: A Morphogenetically Active Implant Material Serving as Metabolic Fuel for Bone Regeneration
Xiaohong WangHeinz C. SchröderWerner E. G. M�llerEmad Tolbasubject
Polymers and PlasticsbiologyPolyphosphateBicarbonatePhosphataseBioengineeringMineralization (biology)Acid anhydrideBiomaterialschemistry.chemical_compoundchemistryBiochemistryTissue engineeringCarbonic anhydraseMaterials Chemistrybiology.proteinBone regenerationBiotechnologydescription
The initial mineralization centers during human bone formation onto osteoblasts are composed of CaCO3 . Those bioseeds are enzymatically formed via carbonic anhydrase(s) in close association with the cell surface of the osteoblasts. Subsequently, the bicarbonate/carbonate anions are exchanged non-enzymatically by inorganic phosphate [Pi ]. One source for the supply of Pi is polyphosphate [polyP] which is a physiological polymer, formed in the osteoblasts as well as in the platelets. The energy-rich acid anhydride bonds within the polyP chain are cleaved by phosphatase(s); during this reaction free-energy might be released that could be re-used, as metabolic fuel, for the maintenance of the steady-state concentrations of the substrates/products during mineralization. Finally it is outlined that polyP, as a morphogenetically active scaffold, is even suitable for 3D cell printing.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-05-15 | Macromolecular Bioscience |