6533b852fe1ef96bd12aaa74

RESEARCH PRODUCT

Modular iminopyridine ligands. Application to the enantioselective copper(II)-catalyzed Henry reaction

Gonzalo BlayIsabel FernándezVictor Hernandez‐olmosEstela ClimentJosé R. Pedro

subject

Nitroaldol reactionNitromethaneOrganic ChemistryEnantioselective synthesischemistry.chemical_elementCopperCatalysisCatalysisInorganic Chemistrychemistry.chemical_compoundchemistryAldol reactionNitroOrganic chemistryPhysical and Theoretical Chemistry

description

Abstract Chiral iminopyridines prepared in a modular fashion from monoterpenic (camphor-derived) ketones and pyridinylalkylamines catalyze the enantioselective Henry (nitro aldol) reaction between nitromethane and o -anisol in the presence of copper(II) acetate, with high yields and good ee (up to 86%) under straightforward experimental conditions without the need for air or moisture exclusion.

yearjournalcountryeditionlanguage
2006-08-01Tetrahedron: Asymmetry
https://doi.org/10.1016/j.tetasy.2006.07.025