6533b852fe1ef96bd12aaaee

RESEARCH PRODUCT

Hematologic malignancies: The exosome contribution in tumor progression

Riccardo AlessandroStefania RaimondoLaura Saieva

subject

Tumor microenvironmentChemokineCell signalingbiologybusiness.industryExosomeMicrovesiclesExtracellular matrixmedicine.anatomical_structureTumor progressionCancer researchbiology.proteinMedicineBone marrowbusiness

description

Abstract The bone marrow, composed of cells, extracellular matrix, and soluble factors, such as cytokines, chemokines and signaling molecules, provides a favorable microenvironment for hematologic tumor progression and for the development of drug resistance. Recently, extracellular vesicles (EVs), released by tumor and surrounding cells, have emerged as important players within the bone marrow niche. Here we will discuss the current knowledge on the EV- mediated crosstalk between tumor and normal cells, in order to better understand how vesicles can contribute to tumor progression. Advances in the knowledge of the role of cell-derived EVs in tumor microenvironment highlight the possibility to use exosomes as new diagnostic and prognostic tools in clinical practice.

yearjournalcountryeditionlanguage
2020-01-01
https://doi.org/10.1016/b978-0-12-816053-4.00004-3