6533b852fe1ef96bd12aabb2

RESEARCH PRODUCT

Uptake of Bead-Adsorbed Versus Soluble Antigen by Bone Marrow Derived Dendritic Cells Triggers Their Activation and Increases Their Antigen Presentation Capacity

Konrad ReskeHans-peter DienesMaria MehligChristoph Scheicher

subject

medicine.anatomical_structureChemistryPhagocytosisParticulate materialAntigen presentationImmunologymedicineDendritic cellBone marrowPhenotypeSoluble antigenCell biology

description

The property to internalize particles has for long time been ascribed primarily to macrophages. DC in contrast were considered generally as phagocytosis negative. Fully mature DC which can be isolated from various tissues of the body do indeed not take up particulate material; however immature DC which arise in differentiating bone marrow cultures do exhibit phagocytic capacity1. Consistent with their immature phenotype epidermal Langerhans cells were also described to possess phagocytic potential2.

yearjournalcountryeditionlanguage
1995-01-01
https://doi.org/10.1007/978-1-4615-1971-3_56