6533b852fe1ef96bd12aad37

RESEARCH PRODUCT

A novel RNA-binding motif in influenza A virus non-structural protein 1.

Diane E. ZimmermanDiane E. ZimmermanYuanpeng HuangRoberto TejeroRoberto TejeroGaetano T. MontelioneGaetano T. MontelioneRobert M. KrugChen-ya ChienChen-ya ChienCarlos B. RiosCarlos B. Rios

subject

Helix bundleModels MolecularBinding SitesMagnetic Resonance SpectroscopyChemistryStructural proteinViral Nonstructural ProteinsAntiparallel (biochemistry)medicine.disease_causeVirusProtein Structure SecondaryBiochemistryStructural BiologyInfluenza A virusInfluenza A virusmedicineNucleic acidRNAStructural motifMolecular BiologySterile alpha motifDimerization

description

The solution NMR structure of the RNA-binding domain from influenza virus non-structural protein 1 exhibits a novel dimeric six-helical protein fold. Distributions of basic residues and conserved salt bridges of dimeric NS1(1-73) suggest that the face containing antiparallel helices 2 and 2′ forms a novel arginine-rich nucleic acid binding motif.

yearjournalcountryeditionlanguage
1997-11-14Nature structural biology
10.1038/nsb1197-891https://pubmed.ncbi.nlm.nih.gov/9360601