Susceptibility variants for obesity and type 2 diabetes mellitus in the population of Latvia

6533b852fe1ef96bd12ab0c1

RESEARCH PRODUCT

Susceptibility variants for obesity and type 2 diabetes mellitus in the population of Latvia

subject

TCF7L2 adiponectin diabetes Molecular biology diabēts adiponektīns Bioloģija FTO AGRP Molekulārā bioloģija

description

Darbs ietver pētījumus par riska gēnu lokusos esošo biežo variantu saistību ar 2.tipa cukura diabētu (T2D) un aptaukošanos Latvijas populācijā. Pētījumu parādīja, ka potenciāli funkcionāls variants AGRP asociējas ar paaugstinātu ĶMI. Savukārt, adiponektīna gēna rajonā esošie varianti nav uzskatāmi par būtiskiem aptaukošanās un T2D riska faktoriem mūsu populācijā, bet iespējams ir iesaistīti kardiovaskulāro saslimšanu patoģenēzē. Varianti TCF7L2 ir nozīmīgi T2D riska faktori pacientiem ar normālu ķermeņa svaru. Iegūtie dati papildina informāciju par FTO un TMEM18 rajonos esošo adipozitātes riska variantu saistību ar T2D neatkarīgi no to ietekmes uz izmaiņām ĶMI. Varianti FTO ceturtajā intronā iespējams saistās ar citiem T2D patoģenēzes mehānismiem nekā pirmajā intronā esošie SNP.

year	journal	country	edition	language
2014-01-01

https://dspace.lu.lv/dspace/handle/7/4955

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