Peļu aktivitātes izmaiņas atklātā lauka testā pēc insulta modelēšanas

6533b852fe1ef96bd12ab0e8

RESEARCH PRODUCT

Peļu aktivitātes izmaiņas atklātā lauka testā pēc insulta modelēšanas

subject

lokomotorā aktivitāte Farmācija insults peles atklātā lauka tests VCAo

description

Išēmisks insults var izraisīt gan neiroloģiskas izmaiņas, tai skaitā sensorimotorās funkcijas un izziņas traucējumus, gan uzvedības izmaiņas. Atklātā lauka tests tiek plaši izmantots, lai novērtētu un analizētu peļu spontāno jeb vispārējo lokomotoro aktivitāti. Bakalaura darba mērķis ir izvērtēt peļu aktivitāti sešus mēnešus pēc insulta modelēšanas, izmantojot atklātā lauka testu. Iegūtie rezultāti rāda, ka Stroke grupas peles uzrāda ievērojami lielāku aktivitāti, griežoties pretpulksteņrādītāja virzienā, salīdzinot gan ar Naive, gan ar Sham grupas pelēm, kas norāda uz insulta bojājumu kontralaterālajā pusē. Naive grupas pelēm ievērojami samazinās aktivitāte, salīdzinot ar pirmo testēšanas reizi, turpretī Sham un Stroke grupas peles neuzrāda tik būtisku aktivitāšu samazināšanos sešu mēnešu periodā.

year	journal	country	edition	language
2020-01-01

https://dspace.lu.lv/dspace/handle/7/52088

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