6533b852fe1ef96bd12ab618
RESEARCH PRODUCT
Genome-wide association studies identify 137 loci for DNA methylation biomarkers of ageing
Nicole Probst-henschNicole Probst-henschIdil YetIdil YetRui XiaJordana T. BellLuigi FerrucciHannah R ElliottJaakko KaprioMelanie WaldenbergerMika KähönenSeyma KatrinliPaul ElliottKathryn L. LunettaJosine L. MinTeemu PalviainenScott M. RatliffDan MasonXiaochuan WangDonna K. ArnettPaolo VineisStefania BandinelliLinda BroerToshiko TanakaDaniel L. MccartneyFalk W. LohoffPei-lun KuoRoger L. MilneRoger L. MilneAke T. LuStephen S. RichSilvia PolidoroKaren N. ConneelyAndrew M. McintoshJeesun JungDavid Van Den BergYunzhang WangMarianne NygaardMarianne NygaardAyoung JeongAyoung JeongKonstantin StrauchKonstantin StrauchEric BoerwinkleMassimo ManginoMelissa C. SoutheyMelissa C. SoutheyCaroline HaywardJack A. TaylorEco J. C. De GeusEco J. C. De GeusTherese TillinSteve HorvathBeate RitzPeter DurdaAnn Zenobia MooreAndré G. UitterlindenAnnette PetersSilva KaselaDavid J. PorteousJames G. WilsonJames G. WilsonWei ZhaoTerho LehtimäkiMaria K. SobczykElina SillanpääElina SillanpääAdolfo CorreaRebecca C. RichmondZongli XuMyriam FornagePamela R. Matias-garciaMedea ImbodenMedea ImbodenIan J. DearyAlicia K. SmithJie YaoJohn WrightDorret I. BoomsmaDorret I. BoomsmaJoanne M. MurabitoMette SoerensenMette SoerensenGail DaviesJames S. PankowPashupati P. MishraAlexandra M. BinderJennifer A. SmithSara HäggGibran HemaniJoyce B. J. Van MeursChristian GiegerMiina OllikainenJenny Van DongenJenny Van DongenOliver RobinsonMarguerite R. IrvinWei ChenPei-chien TsaiPei-chien TsaiPei-chien TsaiCaroline L. ReltonShengxu LiJacob K. KresovichRiccardo E. MarioniJonas Mengel-fromJonas Mengel-fromDeborah A. LawlorXiuqing GuoMatthijs D. Van Der ZeeMatthijs D. Van Der ZeeNancy L. PedersenSarah E. HarrisDianjianyi SunRosie M. WalkerPierre Antoine DuguéPierre Antoine DuguéOlli T. RaitakariOlli T. RaitakariLaura M. RaffieldKaare ChristensenKaare ChristensenHemant K. TiwariDale P. SandlerAlexander P. ReinerAmit PatkiLili MilaniJerome I. RotterTom G. RichardsonSharon L.r. Kardiasubject
African americanGenetics0303 health sciencesdNaMGenome-wide association studyBiologyGenome3. Good health03 medical and health sciences0302 clinical medicineAgeingDNA methylationParental longevityEpigenetics030217 neurology & neurosurgery030304 developmental biologydescription
AbstractBiological ageing estimators derived from DNA methylation (DNAm) data are heritable and correlate with morbidity and mortality. Leveraging DNAm and SNP data from >41,000 individuals, we identify 137 genome-wide significant loci (113 novel) from meta-analyses of four epigenetic clocks and epigenetic surrogate markers for granulocyte proportions and plasminogen activator inhibitor 1 levels, respectively. We report strong genetic correlations with longevity and lifestyle factors such as smoking, education, and obesity. Significant associations are observed in polygenic risk score analysis and to a lesser extent in Mendelian randomization analyses. This study illuminates the genetic architecture underlying epigenetic ageing and its shared genetic contributions with lifestyle factors and longevity.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-06-30 |