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RESEARCH PRODUCT
Bloodstream Infections in Hospitalized Patients with COVID-19: A Systematic Review and Meta-Analysis
Claudia MarinoMariachiara IppolitoFrancesca Romana CatalanottoCarlotta FilisinaAndrea CortegianiGiovanni MisseriAntonino GiarratanoBarbara SimoneGiulia Catalisanosubject
Microbiology (medical)medicine.medical_specialtyCoronavirus disease 2019 (COVID-19)bloodstream infectionsbusiness.industryHospitalized patientsQH301-705.5Mortality ratereviewCOVID-19Subgroup analysisMicrobiologyArticlePrimary outcomeVirologyInternal medicineMeta-analysisMedicineIn patientBiology (General)businessSystematic searchdescription
Background: Little is known about the occurrence of bloodstream infections in hospitalized patients with COVID-19 and the related clinical consequences. The aim of this systematic review and meta-analysis was to estimate the pooled occurrence of BSIs among hospitalized patients with COVID-19 and mortality of this patient population. Methods: A systematic search was performed on PubMed, EMBASE, and Web of Science from inception to 19 April 2021. The primary outcome was the occurrence of BSIs among hospitalized patients with COVID-19. The secondary outcome was mortality at the longest available follow-up. Results: Forty-six studies met the inclusion criteria, with a total of 42,694 patients evaluated. The estimated occurrence of BSIs was 7.3% (95% CI 4.7–1.1%) among hospitalized patients with COVID-19, with a mortality rate of 41% (95% CI 30%–52.8%). The subgroup analysis conducted on patients admitted to ICU provided an estimated occurrence of 29.6% (95% CI 21.7%–38.8%). A higher occurrence of BSI was observed in patients with COVID-19, in comparison with patients without COVID-19 (OR 2.77
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-09-23 | Microorganisms |