6533b853fe1ef96bd12ac048
RESEARCH PRODUCT
Clorgyline effect on pineal melatonin biosynthesis in adrenalectomized rats pretreated with 6-hydroxydopamine
Gregory F. OxenkrugR. RiemannSt. ReussP. J. Requintinasubject
medicine.medical_specialtySuperior cervical ganglionHydroxydopaminebiologyChemistryMelatoninPineal glandmedicine.anatomical_structureEndocrinologyClorgylineInternal medicinemedicinebiology.proteinAntidepressantSerotoninMonoamine oxidase Amedicine.drugdescription
The response to administration of the specific monoamine oxidase A (MAO-A) blocker clorgyline was investigated in adult male Sprague-Dawley rats which were adrenalectomized four days prior to treatment or were additionally sympathectomized as newborns by injection of 6-hydroxydopamine. In both groups, the contents of pineal indoles melatonin and N-acetylserotonin were augmented, and the contents of 5-hydroxyindoleacetic acid and 5-hydroxyindoletryptophol decreased 90 min following clorgyline injections when compared to rats receiving saline. The observed responses were less pronounced in rats both adrenalectomized and sympathectomized. The results are in line with the hypothesis that preservation from oxidation of both MAO-A substrates, noradrenaline and serotonin, upon clorgyline administration contributes to the observed increase in melatonin biosynthesis thought to be associated with the antidepressant effects of MAO inhibition.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1994-01-01 |