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RESEARCH PRODUCT

Orthotopic Mouse Models of Urothelial Cancer

Akihiro GorikiIgor MoskalevPeter C. BlackSamir BidnurPeter A. RavenW. Jäger

subject

0301 basic medicinebusiness.industry03 medical and health sciences030104 developmental biology0302 clinical medicineImmune systemMurine tumorCell cultureIn vivo030220 oncology & carcinogenesisChemical carcinogensIntravesical instillationCancer researchMedicineUrothelial cancerbusiness

description

Orthotopic mouse models of urothelial cancer are essential for testing novel therapies and molecular manipulations of cell lines in vivo. These models are either established by orthotopic inoculation of human (xenograft models) or murine tumor cells (syngeneic models) in immunocompromised or immune competent mice. Current techniques rely on inoculation by intravesical instillation or direct injection into the bladder wall. Alternative models include the induction of murine bladder tumors by chemical carcinogens (BBN) or genetic engineering (GEM).

yearjournalcountryeditionlanguage
2017-09-10
https://doi.org/10.1007/978-1-4939-7234-0_15